Federal government websites often end in. The site is secure. For patients with asthma, eosinophilic airway inflammation is associated with poor lung function, increased disease severity, reduced quality of life and increased risk of exacerbations [ 12 ]. As such, several biologic therapies targeting cytokines involved in eosinophil survival and activation have been developed, with the aim of reducing eosinophilic inflammation [ 3 ]. The response to these cytokine-targeting biologics has typically been assessed by monitoring clinical outcomes. Reductions in blood eosinophils have also been monitored [ 2 ], since these cells are easily accessible and are reflective of eosinophilic airway inflammation [ 45 ]. However, the utility of sputum eosinophils as a biomarker for assessing the therapeutic response to biologic therapies remains an area of ongoing scientific debate and has been largely unexplored, vad menas med sputum eosinofili to logistical challenges associated with their collection and measurement.
Eosinophilia e-o-sin-o-FILL-e-uh is a higher than normal level of eosinophils. Eosinophils are a type of disease-fighting white blood cell. This condition most often indicates a parasitic infection, an allergic reaction or cancer. You can have high levels of eosinophils in your blood blood eosinophilia or in tissues at the site of an infection or inflammation tissue eosinophilia. Tissue eosinophilia may be found in samples taken during an exploratory procedure or in samples of certain fluids, such as mucus released from nasal tissues.